Trabalho do CMACF é foco de editorial
28 de novembro de 2012 - 17:30
No seguinte editorial publicado na Am J Physiol Renal Physiol 302: F957–F958, 2012;
doi:10.1152/ajprenal.00042.2012.
foi citado o trabalho do CMACF (Prof Dr Nilberto Robson Falcão do Nascimento)
Cardenolides and bufadienolides as hormones: what is missing?
David Lichtstein, Haim Rosen, and Moran Dvela
Department of Medical Neurobiology and 2Departments of Microbiology and Molecular Genetics, Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem, Israel
…”In a paper by Arnaud- Batista and colleagues (2), published in an issue of the American Journal of Physiology-Renal Physiology, the authors show that ouabain and especially, bufalin induce diuresis, natriuresis, and kaliuresis in the isolated intact rat kidney. A Src family kinase inhibitor, PP2, and UO126, a highly selective inhibitor of both MEK1 and MEK2, blunted the steroid effects. These results demonstrate for the first time the relevance of the signaling effects of cardenolides and bufadienolides in their natriuretic influence on isolated intact kidney function, pointing to the possible physiological role of these compounds as natriuretic hormones”…
Parabens aos autores!